medication for depression

Monoamine oxidase inhibitors first medication for depression

MAO(Monoamine oxidase inhibitors) first medication for depression

It is mainly for depression medication and was introduced in the 1950s, the first depression medicine, and nowadays less popular than others.

The days are gone when Depression was limited to adults. From kids to adults, everyone can show signs and symptoms of Depression. We have classified different signs and symptoms based on age and sex. 


In Women:

Symptoms in women may vary from one to another, but they may show some signs mentioned below:

  • Women feel anxious and terrified; 
  • They blame themselves for the Depression; 
  • Women usually feel sad, valueless, and lazy when depressed; 
  • They are more expected to avoid fights when depressed; 
  • Women feel tired and nervous; 
  • Woman loses interest in pleasurable activities;
  • They are prone to suicidal thoughts or attempts of suicide;
  • Women face sleep disorders; sleeping too much or too little, insomnia;
  • They face Fluctuations in appetite, either eating too much or too small;
  • Some Physical symptoms can be aches and pains, cramps, headaches, digestive issues, breast tenderness; 
  • They may get Panic attacks.


In Men:

Symptoms in Men differ from women. While women are more vocal about their issues, men tend to hide them. It is essential to know that men are more likely to attempt suicide and harm themselves than women.

  • Men feel protected;
  • They blame others for their Depression;
  • Men tend to feel more short-tempered and angry;
  • They are more accepted to create conflicts;
  • Men turn to alcohol, TV, sex, or sports;
  • They feel disconcerted and edgy;
  • Men hide feelings of self-doubt and despair. They consider it a sign of weakness.

 In Young-Adult:

Whether it’s the college or personal relationship, there are many factors responsible for Depression in Young-Adults. Some signs and symptoms in Adults are:

  • Young-Adults may feel Sad, Anxious, and Empty;
  • They may also feel Hopeless, Guilty, Worthless, and Helpless;
  • They are easily irritable and restless;
  • Lack of energy, Problems concentrating and remembering information or making decisions;
  • Youngsters face problems falling asleep, staying asleep, or sleeping too much;
  • They have a loss of appetite or overeating;
  • Thoughts of suicide or suicide attempts are common in them;
  • They often complain about Aches, cramps, pains, headaches, or digestive problems that do not go away.

In Teenagers:

Depression symptoms in teenagers can vary by situation. Nonetheless, variations in teenager’s emotions and behavior are:


  • Teenagers may feel sad, which can include crying sessions for no apparent reason;
  • They may feel frustrated or angry, even over minor difficulties;
  • Feeling hopeless or empty and often Irritated or in an annoying mood;
  • They may face the Loss of interest or pleasure in activities they usually have fun;
  • No interest in family or friends conflicts and distancing themselves;
  • They have low self-esteem and feelings of worthlessness or guilt;
  • They are stuck on past failures or exaggerated self-blame or self-criticism;
  • Extreme sensitivity to rejection or Loss, and they need to have too much reassurance;
  • Teenagers face trouble making decisions, thinking, concentrating, and remembering things;
  • They are unsure of their life and how their future is grey and depressing;
  • They frequently think of death, dying, or suicide;
  • They start Using alcohol or drugs often;
  • Teenagers begin to Frequently complain of unexplained body aches and headaches, which may comprise recurrent visits to the school nurse;
  • They may perform poorly at school or frequently absent from school;
  • Teenagers start to pay less attention to personal hygiene or appearance;
  • They have fits of Angry outbursts, disruptive or risky behavior, or other acting-out outbursts
  • They can attempt Self-harm like cutting, excessive piercing, or tattooing
  • They may isolate themselves socially and Make suicide plans or suicide attempts.


In Children:

Depression can also be seen in children. One has to Know the Signs and Symptoms to identify Depression.

  • They may seem more Irritated or angry;
  • Kids may feel Continuous fits of sadness and hopelessness;
  • They may be sensitive to rejection;
  • You will start to notice changes in their appetite and sleep;
  • Kids may have Vocal outbursts or cry for trivial reasons;
  • They may face trouble in concentrating;
  • Kids may even show Fatigue and low energy;
  • Physical complaints such as stomach aches, headaches will become common. And they won’t respond to treatment;
  • They may show less interest or energy during events and activities at home or with friends, in school, extracurricular activities, and other hobbies;
  • Kids may also show signs of suicidal thoughts and death.


It is very uncommon in kids under 12 to try self-harm or suicide – and if they do it recklessly when they are mad or furious. Younger girls are more prone to attempt suicide, yet boys are bound to harm themselves when they try. Youngsters with a family background of cruelty, alcohol misuse, or physical or sexual damage are at more danger for self-harm. 

How does this medication work mentally and physically?

MAOIs work Mentally with the chemicals in your brain called neurotransmitters (central nervous system) that allow brain cells to communicate, respond with each other.
Depression is a thought process to be caused by low neurotransmitters dopamine, serotonin, and norepinephrine, which collectively are called monoamines.
Also, A chemical found naturally in the human body, and monoamine oxidase removes these neurotransmitters.

By inhibiting monoamine oxidase, MAOIs allow more of these neurotransmitters to remain in the brain, 

Thus elevating mood through improved brain cell communication.

The side effect of this medication:-

MAOIs is a potent medication, and if you want to interact with alcohol, then you may see some harmful effects, like:

  • Fatigue
  • Memory loss
  • Breathing problem
  • Seizures
  • Dizziness

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